Regioselective routes to orthogonally-substituted aromatic MIDA boronates.
نویسندگان
چکیده
A series of tetrasubstituted aromatics has been synthesized, many of which are based on elaborated N-methyliminodiacetic acid (MIDA)-boronates. A sequence employing nitration, bromination, stepwise Suzuki-Miyaura (SM) coupling with a boronic acid, then base-mediated unmasking of the boronic acid from the MIDA-boronate and a second SM-coupling has led to our desired, mainly 1,2,4,5-substituted tetrasubstituted aromatic targets.
منابع مشابه
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 14 28 شماره
صفحات -
تاریخ انتشار 2016